BMI Course Information
BMI 101 Introduction to Bioinformatics (3)
Instructor Information |
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Fall 2009 |
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Spring 2009 |
Course not offered |
Catalog Description
Introduction to existing and future applications in bioinformatics. Introduces topics in translational bioinformatics, such as sequence alignment, the Human Genome Project, genomics, proteomics, gene expression analysis, genome wide association studies and next generation sequencing.
Textbook and Other Materials
Shortliffe, E. Cimino, J. (Editors) Biomedical Informatics: Computer Applications in Health Care and Biomedicine (Health Informatics). Third edition.
Course Learning Outcomes
Students who complete this course will be able to:
1. Identify and describe the four major areas of biomedical informatics.
2. Identify and describe current applications of informatics in translational bioinformatics.
3. Critically appraise existing applications and methods in this areas.
4. Place existing applications in the context of the history of the field.
5. Describe likely future applications and probable growth areas.
Major Topics and Time Covered
- Introduction to Biomedical Informatics (2 weeks)
- Introduction to Translational Bioinformatics (1 week)
- Overview of relevant molecular biology and genetics topics: DNA, proteins, transcription, translation (1 week)
- Introduction to laboratory techniques that generate bioinformatics data: PCR, sequencing, microarrays (1 week)
- Sequence alignment, dynamic programming, BLAST (2 weeks)
- Disease association analysis: mutations, Single Nucleotide Polymorphisms, Linkage Disequilibrium, haplotypes, Genome Wide Association Studies (2 weeks)
- Gene expression analysis (2 weeks)
- Copy number variants and loss of heterozygosity (2 weeks)
- Future Applications and Next Generation Sequencing (1 weeks)